Researchers Find Cause Of Cognitive Decline In Seniors

According to scientists at Mount Sinai School of Medicine, these spines receive an important class of synapses that are involved with the process of learning. The discovery provides the medical community with a new therapeutic target to help prevent this loss of function.

“Millions of aging seniors suffer from dementia and Alzheimer’s disease,” explains Jesse Slome, director of the American Association for Long-Term Care Insurance.  These conditions account for the longest and most costly causes for long term health care.

When a person ages they lose certain spines the researchers noted.  We did not know which ones and how their loss impacted cognition.  The new study shows which spines are lost and what their impact is on brain function, giving us a foundation to research treatment interventions to protect against age-related cognitive decline.

The research team studied six young adult and nine older rhesus monkeys as they participated in a delayed response test. The monkeys watched as food was baited and hidden, and then a screen was put in front of them so they could no longer see the location of the hidden reward.

At the beginning of the test, the screen was raised immediately and the monkeys were able to find the food reward right away. The subject’s memory was tested by increasing the time that the reward was blocked from view to test if the monkeys retained where the reward was placed over longer intervals of time. Aged monkeys performed significantly worse on the tests than young monkeys, especially as the time intervals increased.

The researchers determined that the older monkeys lacked the thin spines but retained the larger spines, indicating that the loss of the thin spines may be responsible for the monkeys’ inability to learn and retain information during the test. For the first time, the researchers determined that the large spines were stable, which provides a synaptic basis for the observation that expertise and skills learned early in life are often maintained into old age. 

The study is published in the June 2 issue of the Journal of Neuroscience.

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